Sanford is a larger medium-sized city located in the state of Florida. With a population of 65,394 people and 20 associated neighborhoods, Sanford is the 53rd largest community in Florida.

Also of interest is that Sanford has more people living here who work in computers and math than 95% of the places in the US.

A relatively large number of people in Sanford telecommute to their jobs. Overall, about 16.67% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

The percentage of people in Sanford who are college-educated is somewhat higher than the average US community of 21.84%: 26.81% of adults in Sanford have at least a bachelor's degree.

The per capita income in Sanford in 2022 was $32,828, which is lower middle income relative to Florida, and middle income relative to the rest of the US. This equates to an annual income of $131,312 for a family of four. However, Sanford contains both very wealthy and poor people as well.

Sanford is an extremely ethnically-diverse city. The people who call Sanford home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Sanford residents report their race to be White, followed by Black or African-American. Sanford also has a sizeable Hispanic population (people of Hispanic origin can be of any race). People of Hispanic or Latino origin account for 27.39% of the city’s residents. Important ancestries of people in Sanford include German, Irish, English, Italian, and Polish.

Foreign born people are also an important part of Sanford's cultural character, accounting for 18.27% of the city’s population.

The most common language spoken in Sanford is English. Other important languages spoken here include Spanish and Langs. of India.