Murphysboro is a somewhat small city located in the state of Illinois. With a population of 7,044 people and four associated neighborhoods, Murphysboro is the 279th largest community in Illinois.

One interesting thing about the economy is that relatively large numbers of people worked from their home: 13.39% of the workforce. While this number may seem small overall, as a fraction of the total workforce this is high compared to the rest of the county. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Being a small city, Murphysboro does not have a public transit system used by locals to get to and from work.

The citizens of Murphysboro are slightly better educated than the national average of 21.84% for all cities and towns, with 24.26% of adults in Murphysboro having a bachelor's degree or advanced degree.

The per capita income in Murphysboro in 2022 was $29,101, which is low income relative to Illinois, and lower middle income relative to the rest of the US. This equates to an annual income of $116,404 for a family of four. However, Murphysboro contains both very wealthy and poor people as well.

Murphysboro is a very ethnically-diverse city. The people who call Murphysboro home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Murphysboro residents report their race to be White, followed by Black or African-American. Important ancestries of people in Murphysboro include German, Irish, English, Italian, and French.

The most common language spoken in Murphysboro is English. Other important languages spoken here include Spanish and Italian.