Plaquemine is a somewhat small city located in the state of Louisiana. With a population of 5,956 people and four associated neighborhoods, Plaquemine is the 76th largest community in Louisiana.

A relatively large number of people in Plaquemine telecommute to their jobs. Overall, about 9.45% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Plaquemine is a small city, and as such doesn't have a public transit system that people use to get to and from their jobs every day.

The percentage of adults in Plaquemine with college degrees is slightly lower than the national average of 21.84% for all communities. 15.75% of adults in Plaquemine have a bachelor's degree or advanced degree.

The per capita income in Plaquemine in 2022 was $31,192, which is upper middle income relative to Louisiana, and middle income relative to the rest of the US. This equates to an annual income of $124,768 for a family of four. However, Plaquemine contains both very wealthy and poor people as well.

Plaquemine is an extremely ethnically-diverse city. The people who call Plaquemine home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Plaquemine residents report their race to be Black or African-American, followed by White. Important ancestries of people in Plaquemine include French, Irish, German, African, and Italian.

The most common language spoken in Plaquemine is English. Other important languages spoken here include Italian and Spanish.