Plaquemine is a somewhat small city located in the state of Louisiana. With a population of 5,985 people and four associated neighborhoods, Plaquemine is the 76th largest community in Louisiana.

Being a small city, Plaquemine does not have a public transit system used by locals to get to and from work.

The percentage of adults in Plaquemine who are college-educated is close to the national average for all communities of 21.84%: 17.16% of the adults in Plaquemine have a bachelor's degree or advanced degree.

The per capita income in Plaquemine in 2022 was $31,360, which is upper middle income relative to Louisiana, and lower middle income relative to the rest of the US. This equates to an annual income of $125,440 for a family of four. However, Plaquemine contains both very wealthy and poor people as well.

Plaquemine is an extremely ethnically-diverse city. The people who call Plaquemine home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Plaquemine residents report their race to be Black or African-American, followed by White. Important ancestries of people in Plaquemine include French, Irish, German, Italian, and African.

The most common language spoken in Plaquemine is English. Other important languages spoken here include Italian and Polish.