De Soto is a somewhat small city located in the state of Missouri. With a population of 6,493 people and four associated neighborhoods, De Soto is the 112th largest community in Missouri.

A relatively large number of people in De Soto telecommute to their jobs. Overall, about 15.11% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

In De Soto, however, the average commute to work is quite long. On average, people spend 33.26 minutes each day getting to work, which is significantly higher than the national average.

The percentage of people in De Soto with college degrees is quite a bit lower than the national average for cities and towns of 21.84%: just 11.32% of people over 25 have a bachelor's degree or advanced degree.

The per capita income in De Soto in 2022 was $24,680, which is lower middle income relative to Missouri, and low income relative to the rest of the US. This equates to an annual income of $98,720 for a family of four. However, De Soto contains both very wealthy and poor people as well.

De Soto is a somewhat ethnically-diverse city. The people who call De Soto home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of De Soto residents report their race to be White, followed by Native American. Important ancestries of people in De Soto include German, English, Irish, Italian, and Dutch.

The most common language spoken in De Soto is English. Other important languages spoken here include Italian and Spanish.