Doniphan is a very small city located in the state of Missouri. With a population of 1,782 people and two associated neighborhoods, Doniphan is the 293rd largest community in Missouri.

A relatively large number of people in Doniphan telecommute to their jobs. Overall, about 13.25% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

The citizens of Doniphan are slightly less educated than the national average of 21.84% for the average city or town: 14.78% of adults in Doniphan have a bachelor's degree or advanced degree

The per capita income in Doniphan in 2022 was $20,016, which is low income relative to Missouri and the nation. This equates to an annual income of $80,064 for a family of four. However, Doniphan contains both very wealthy and poor people as well. Doniphan also has one of the higher rates of people living in poverty in the nation, with 30.21% of its population below the federal poverty line.

Doniphan is a somewhat ethnically-diverse city. The people who call Doniphan home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Doniphan residents report their race to be White, followed by Black or African-American. Important ancestries of people in Doniphan include German, Irish, English, Scots-Irish, and French.

The most common language spoken in Doniphan is English. Other important languages spoken here include Italian and Spanish.