North Wilkesboro is a very small town located in the state of North Carolina. With a population of 4,412 people and five associated neighborhoods, North Wilkesboro is the 188th largest community in North Carolina.

A relatively large number of people in North Wilkesboro telecommute to their jobs. Overall, about 16.30% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Residents of the town have the good fortune of having one of the shortest daily commutes compared to the rest of the country. On average, they spend only 16.37 minutes getting to work every day.

The education level of North Wilkesboro citizens is a little higher than the average for US cities and towns: 24.66% of adults in North Wilkesboro have at least a bachelor's degree.

The per capita income in North Wilkesboro in 2022 was $28,364, which is lower middle income relative to North Carolina and the nation. This equates to an annual income of $113,456 for a family of four. However, North Wilkesboro contains both very wealthy and poor people as well.

North Wilkesboro is a very ethnically-diverse town. The people who call North Wilkesboro home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of North Wilkesboro residents report their race to be White, followed by Black or African-American. Important ancestries of people in North Wilkesboro include English, German, Italian, Irish, and Czech.

The most common language spoken in North Wilkesboro is English. Other important languages spoken here include Spanish and Chinese.