Chillicothe is a medium-sized city located in the state of Ohio. With a population of 21,769 people and 11 associated neighborhoods, Chillicothe is the 78th largest community in Ohio.

The population of Chillicothe overall has a level of education that is slightly above the US average for all US cities and towns of 21.84%. Of adults 25 and older in Chillicothe, 21.85% have at least a bachelor's degree.

The per capita income in Chillicothe in 2022 was $34,688, which is middle income relative to Ohio and the nation. This equates to an annual income of $138,752 for a family of four. However, Chillicothe contains both very wealthy and poor people as well.

Chillicothe is a somewhat ethnically-diverse city. The people who call Chillicothe home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Chillicothe residents report their race to be White, followed by Black or African-American. Important ancestries of people in Chillicothe include German, English, Irish, Italian, and Scottish.

The most common language spoken in Chillicothe is English. Other important languages spoken here include Spanish and German/Yiddish.