St. Matthews is a very small town located in the state of South Carolina. With a population of 1,834 people and two associated neighborhoods, St. Matthews is the 146th largest community in South Carolina.

Telecommuters are a relatively large percentage of the workforce: 13.06% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

As is often the case in a small town, St. Matthews doesn't have a public transportation system that people use for their commute.

The overall education level of St. Matthews citizens is substantially higher than the typical US community, as 30.38% of adults in St. Matthews have at least a bachelor's degree, and the average American community has 21.84%.

The per capita income in St. Matthews in 2022 was $33,337, which is upper middle income relative to South Carolina, and middle income relative to the rest of the US. This equates to an annual income of $133,348 for a family of four. However, St. Matthews contains both very wealthy and poor people as well. St. Matthews also has one of the higher rates of people living in poverty in the nation, with 31.11% of its population below the federal poverty line.

St. Matthews is an extremely ethnically-diverse town. The people who call St. Matthews home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of St. Matthews residents report their race to be Black or African-American, followed by White. Important ancestries of people in St. Matthews include English, German, Irish, Scottish, and Russian.

The most common language spoken in St. Matthews is English. Other important languages spoken here include Polish and Spanish.