Muleshoe is a somewhat small city located in the state of Texas. With a population of 5,218 people and two associated neighborhoods, Muleshoe is the 371st largest community in Texas.

Muleshoe is a small city, and as such doesn't have a public transit system that people use to get to and from their jobs every day.

The citizens of Muleshoe are slightly less educated than the national average of 21.84% for the average city or town: 13.14% of adults in Muleshoe have a bachelor's degree or advanced degree

The per capita income in Muleshoe in 2022 was $32,533, which is middle income relative to Texas and the nation. This equates to an annual income of $130,132 for a family of four. However, Muleshoe contains both very wealthy and poor people as well.

Muleshoe is an extremely ethnically-diverse city. The people who call Muleshoe home describe themselves as belonging to a variety of racial and ethnic groups. People of Hispanic or Latino origin are the most prevalent group in Muleshoe, accounting for 72.01% of the city’s residents (people of Hispanic or Latino origin can be of any race). The greatest number of Muleshoe residents report their race to be White, followed by Black or African-American. Important ancestries of people in Muleshoe include English, Scottish, Irish, German, and South African.

In addition, Muleshoe has a lot of people living here who were born outside of the US (19.66%).

The most common language spoken in Muleshoe is Spanish. Other important languages spoken here include English and Native American languages.